DMT Microdosing Produces Antidepressant and Anxiolytic Effects

Photograph of DMT crystals
Photograph of DMT crystals

In a recent publication (Cameron and coworkers, ACS Chemical Neuroscience, 2019), the Olson Lab demonstrates for the first time that psychedelic microdosing—the practice of administering subhallucinogenic doses on a chronic, intermittent schedule—may reduce depression and ease anxiety.  This work suggests that the hallucinogenic properties of psychedelic compounds like DMT might not be necessary for their therapeutic effects.

More information at https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.8b00692