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Detection of OG:A Lesion Mispairs by MutY Relies on a Single His Residue and the 2‑Amino Group of 8‑Oxoguanine

July 24, 2020

The chemical basis for detecting rare DNA lesions by base excision repair enzymes has captivated the imagination of the DNA repair field since it represents a statistically improbable feat. A collaboration between Sheila David’s lab and Andrea Lee’s lab at the University of Vermont provided key insights into the lesion recognition process by one such DNA repair enzyme. MutY, and it’s human homolog MUTYH, are adenine glycosylases proficient in locating rare and mutagenic OG:A mispairs and distinguishing them from structurally similar undamaged DNA.

Fast Proton Transfer and Hydrogen Evolution Mediated by [Co₁₃C₂(CO)₂₄]⁴⁻

July 09, 2020

In a recent publication (Berben and coworkers, Journal of American Chemical Society, 2020) the Berben Lab brings to light an approach for enhancing rates of hydrogen evolution using a metal-metal bonded molecular catalyst. Experiments demonstrate that [Co₁₃C₂(CO)₂₄]⁴⁻, containing multiple metal-metal bonds boosts the rate of hydrogen evolution compared to single-site metal complexes.

Catalyzing Enantioselective Si–H Insertions for Silicon-centered Chirality

July 07, 2020

In a recent publication (Jagannathan and coworkers) in the Journal of the American Chemical Society, the Franz lab has joined forces with the Shaw lab to develop a new catalytic Si-H insertion reaction using diarylcarbenes that allows selective synthesis of chiral-at-silicon compounds with high yield and enantioselectivity. The incorporation of silicon-centered chirality into more complex structures such as drug candidates, polymers, and ligands is limited because there is a shortage of synthetic methods to access these chiral molecules.

Driving Torsion Scans with Wavefront Propagation

June 25, 2020

The quantum mechanical potential energy of a molecule along torsion (dihedral angle) degrees of freedom is a crucial factor in the conformational flexibility of molecules, and plays a major role in the development of force fields for molecular simulation.  In a recent publication in the Journal of Chemical Physics, the Wang research group describes an improved workflow for computing these potential energy surfaces using a recursive wavefront propagation algorithm.  The new algorithm improves on existing approaches because it is less likely to get stuck in high-energy local minima a

Direct Solid-State Nucleation and Charge-Transport Dynamics of Alkali Metal-Intercalated M₂Mo₆S₆ (M = K, Rb, Cs) Nanorods

June 25, 2020

In a recent publication (Perryman and coworkers, featured on the back cover of Journal of Materials Chemistry C, “Emerging Investigators” themed issue, available in early August 2020) the Velázquez Lab describes for the first time experimental evidence of microwave-induced 1-dimensional growth of a compositionally modular pseudo-Chevrel-Phase chalcogenide nanorod framework.

Olson Lab Research Featured on the Cover of ACS Chemical Neuroscience

June 19, 2020

In a recent publication, the Olson Lab used a variety of chemical tools to demonstrate that the marine natural product bryostatin 1 increases synaptogenesis while simultaneously reducing the number of protrusions that harbor synapses.  This unique effect has the potential to improve signal-to-noise ratio in the central nervous system and could possible explain why the natural product improves memory.  Bryostatin 1 is currently being investigated for the treatment of Alzheimer’s disease.

Elucidation of the metal-binding site in C-peptide, a hormone related to insulin

June 09, 2020

A recently accepted publication by Heffern and coworkers in Inorganic Chemistry identifies the copper(II) and zinc(II) binding site on a peptide hormone known as C-peptide. C-peptide is made alongside insulin in the pancreas and may help with kidney and blood vessel damage in patients with diabetes. Their findings show that copper(II) and zinc(II) share the same site and compete with each other for binding at the N-terminus of the peptide.

Microwave-assisted synthesis of Ge nanostructures for energy storage

May 22, 2020

Nano-sized galvanic replacement reaction is a powerful tool to synthesize complicate nanostructures. In this work the Kauzlarich lab (Xiao, et al., ACS Applied Nano Materials, 2020) report an unconventional galvanic replacement reaction between GeI₂ and Ag NPs with morphological and compositional control. An inward and outward diffusion mechanism is proposed and supported by imaging the different stages of the reaction and analysis of the products. The unique mechanism allows the reaction to be self-terminated and achieve nanometer-sized accuracy.

Anions control vapochromic and thermochromic properties of [(C₆H₁₁NC)₂Au]⁺ salt

May 22, 2020

Thermochromic or vapochromic dyes change color in response to temperature changes or vapor pressure of organic compounds, which are useful in many applications including sensors, labels for biomaterials, thermal coatings for windows, and optoelectronic devices.  In a recent JACS publication, Lucy Luong (Balch lab) and coworkers describe experiments showed that salts of the [(C₆H₁₁NC)₂Au]⁺ cation with non-coordinating anions such as PF₆⁻, AsF₆⁻ and SbF₆⁻ feature remarkable diversity in their molecular structure, luminescence, and thermochromic

A spectroscopic mimic of the oxygen evolving complex

February 27, 2020

The oxygen evolving complex (OEC) of photosystem II catalyzes the oxidation of water to form molecular oxygen. The S₃-state is currently the last observable intermediate prior to O–O bond formation. Its electronic structure has been assigned to a homovalent Mn(IV)₄ core with an S = 3 ground state. In a recent publication (Lee, Marchiori, et al. JACS), the Agapie (Caltech) and Britt labs synthesized and characterized via XAS and multifrequency EPR spectroscopy a Mn(IV)₄O₄ cuboidal complex.

EPR spectroscopy of iron- and nickel-doped [ZnAl]-layered double hydroxides: modeling active sites in heterogeneous water oxidation catalysts

January 14, 2020

In a new JACS article (https://pubs.acs.org/doi/10.1021/jacs.9b10273) describing a collaboration between the Britt and Gray (Caltech) labs, Sayler et al. describe a set of model materials that facilitate the understanding of individual active sites in the highly active heterogeneous water oxidation catalyst, [NiFe] LDH.  Heterogeneous catalysts often have a high magnetic density of active sites, complicating the interpretation of EPR spectroscopic data.

Thermoelectric composite with improved mechanical and transport properties

January 14, 2020
Synthesis of the composite of the high performance Yb₁₄MgSb₁₁ thermoelectric phase with iron to improve mechanical and transport properties

Thermoelectric materials have been used to provide electricity to spacecraft for decades. In this work the Kauzlarich lab (Perez, et al., ACS Appl. Energy Mater., 2020) in collaboration with Thermal Energy Conversion Research and Advancement Group at NASA-JPL have shown that Yb₁₄MgSb₁₁, one of the candidates for NASA’s next generation of thermoelectric materials, can be composited with iron without reaction upon thermal cycling.

The biosynthetic origins of [FeFe] hydrogenase active site unraveled

January 04, 2020

Hydrogenases are nature’s machines to metabolize H₂. The [FeFe] hydrogenase subtype catalyzes the rapid turnover at its six-iron active site cofactor, the H-cluster, which contains CO, cyanide and a unique azadithiolate (adt) ligand essential for catalysis. In a recent publication (Rao and coworkers, Chemical Science, 2019) the Britt lab identified the biosynthetic precursor of the adt ligand.

Discovery of metastability in the active phase of perovskite solar cells

November 01, 2019

Cesium lead iodide (CsPbI₃) has long been a promising light absorbing material for perovskite solar cells. Researchers from the Navrotsky lab, in a recently published study (J. Am. Chem. Soc. 2019, 141, 14501) conducted calorimetric studies on cubic(α) and orthorhombic(δ) CsPbI₃ polymorphs, obtaining their enthalpies of formation from binary iodides, and discussing the relative stabilities. Cubic phase CsPbI₃, the desirable phase for light absorbing material, is confirmed to be metastable under ambient conditions.