Biosynthesis of the [FeFe]-Hydrogenase with an organometallic Fe2S2 cluster bypasses HydG and HydE maturases


In a study recently published in  JACS, collaborative work between Britt lab and Tom Rauchfuss lab (UIUC) presents the evidence that a synthetic organometallic Fe2S2 cluster can functionally replace two radical SAM enzyme maturases HydG and HydE to allow the biosynthesis of the [FeFe]-hydrogenase. This work unambiguously identifies the organometallic Fe2S2 cluster as an intermediate in the biosynthesis of [FeFe]-hydrogenase catalytic H-cluster. 


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