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That is the question.  Research by the David lab provides answers into the roles for Fe-S clusters, a cofactor more commonly found in redox enzymes, in DNA repair enzymes. In an article in Nature Communications, structural and functional profiling of inherited cancer-associated variants (CAVs) near the [4Fe-4S] cluster cofactor of the human DNA repair enzyme MUTYH, revealed an allosteric network that connects DNA binding at the cofactor to damaged base removal at the active site.  Th

Liquid water can be cooled below 0° C without freezing, a phenomenon known as supercooling.  However, below -50° C, the properties of supercooled water are difficult to measure due to rapid ice crystallization.  There is a long-standing question of whether there exist two distinct phases of liquid water under deeply supercooled conditions, called "high density liquid" and "low density liquid".

A recent publication from the Velázquez lab presents the synthesis of heterointercalant Chevrel phase sulfide compositions, which have been accessed for the first time through rapid microwave-assisted solid-state synthesis, for applications in energy conversion reactions. Through elemental spectroscopic analysis, a chain electron transfer mechanism was investigated and examined by electrochemically reducing CO₂ to elucidate the distribution of electron density and the subsequent binding affinities of CO₂ resulting from the identities of intercalants.

Recently UC Davis Chemistry Professor R. David Britt was honored to represent the US ACS Bader Award winners at the 100th Birthday Memorial Symposium for Alfred R. Bader at his Chemistry alma mater of Queen’s University in Kingston Ontario.

The Queen’s University International Student Chapter of the American Chemical Society (Q-ACS) was excited to host the first-ever Bader Symposium on Monday, November 18th, 2024 at the Isabel Bader Centre for the Performing Arts to celebrate the 100th birthday of the late Dr. Alfred R. Bader this year.

The David Lab recently published an article in ACS Central Science elucidating a key structure-activity relationship for the recognition of mispairs between adenine and the oxidatively damaged 8-oxo-7,8-dihydroguanine (OG) by human DNA repair glycosylase, MUTYH.

Moving society toward a greener future hinges on efficient technologies. Silicon solar cells, currently the leading commercial technology in the solar cell arena, reach energy conversion efficiencies of 18% to 22%, according to the U.S. Department of Energy. That means roughly four-fifths of the energy from the sunlight isn’t being harnessed by current commercial photovoltaic technology.

High Performing Thermoelectric 2D Sb₂Te₃ and Bi₂Te₃ Nanoplates

In a recent publication in Science, the Olson Lab used chemical and molecular tools to elucidate the mechanism of psychedelic-induced neuroplasticity. They found that activation of intracellular 5-HT2A receptors was essential for psychedelics to promote cortical neuron growth. Unlike psychedelics, serotonin is too polar to passively diffuse across cell membranes, and thus, it does not produce the same effects on structural neuroplasticity.

Congratulations to Professor Sheila David (@sheiladavidUCD) for receiving the 2022 Education Award from the Environmental Mutagenesis and Genomics Society (@emgsus).  The EMGS aims to understand and mitigate the impacts of environmental exposures on the genome to protect human health, and strives to promote excellence, diversity and inclusiveness in research, professional development and collaboration. &