A Closer Look at Time Tested Reactions

In a recent publication (Zhu, Li, Tsui and coworkers, J. Am. Chem. Soc. 2019, 141, 6247-6253), the Tantillo and Kurth labs reinvestigated the mechanism of the Davis–Beirut reaction and Cadogan cyclization for 2H-indazole synthesis. At last, the elusive 2H-indazole N-oxide has been isolated, characterized, and modelled. This work highlights the amount of mechanistic insights gained when synthetic chemistry is coupled with computational support!

Read more at https://pubs.acs.org/doi/pdf/10.1021/jacs.8b13481