A chemoenzymatic synthon for carbohydrate synthesis
The Chen Glyco Group reported a new strategy for the synthesis of complex carbohydrates by designing a chemoenzymatic synthon (PMID: 29349857. Accepted article, http://onlinelibrary.wiley.com/doi/10.1002/anie.201712022/abstract). The synthon is easily accessible by chemical synthesis. It can be enzymatically converted to carbohydrate analogs which are readily derivatized chemically to produce desired targets. The method expands the scope of chemoenzymatic synthetic products accessible by commercially available enzymes.