Our major area of current research involves the use of polymer attachment of organic substrates to modify or completely change their reactivity. Our initial efforts in this area revealed that we could induce major changes in reaction selectivity in both conventional synthetic processes and transition-metal catalyzed reactions. For example, in organic cycloaddition reactions, we can selectively cyclize just one of the double bonds of a symmetrical diene to a polymer-supported 1,3-dipole precursor, leaving the other one free for use at a later stage of a synthesis of substituted cyclic ethers. In another instance, organometallic reaction between an alkene and an alkyne can be selectively promoted, and reactions between multiple alkyne units suppressed by use of polymer-attachment strategies. We are pursuing a variety of avenues of research in this area, such as study of the use of entirely novel polymer types for the recycling and reuse of organic and organometallic reagents and catalysts.
Education, Awards and Professional Highlights
- Phi Beta Kappa Award for Teaching Excellence (2006)
- Executive Secretary, UC Cancer Research Coordinating Committee (1999)
- Distinguished Teaching Award (1989)
- Dreyfus Teacher-Scholar (1981-1985)
- Magnar Ronning Award, Teaching Excellence (1979)
- Appointed to faculty, UC Davis (1976)
- NIH Postdoctoral Fellowship (1974-1976)
- Ph.D. Columbia University (1973)
- Louis P. Hammett Award (1973)
- NSF and NIH Predoctoral fellowships (1969-1973)
- B.A. University of Pennsylvania (1969)
- Varela, M. C., S. M. Dixon, M. D. Price, J. E. Merit, P. E. Berget, S, Shiraki, M. J. Kurth and N. E. Schore. 2007. Comparison of enantioselective reductions using bead and monolith 'disk' polymer formulations of CBS catalysts. Tetrahedron, 63, in press.
- Hok, S. and N. E. Schore. 2006. Synthesis of 2-arylcycloalka-2,4-dienones using sulfone-based methodology. J. Org. Chem., 71, 1736.
- Berget, P. E. and N. E. Schore. 2006. Recycling titanocene dichloride from the Petasis methylenation reaction. Organometallics, 25, 552.
- Berget, P. E. and N. E. Schore. 2005. Catalytically active, recyclable polymeric. Titanocene disks: a batch-flow reactor. Tet. Lett., 46, 8869.
- Song, Y., R. E. Haddad, S.-L. Jia, S. Hok, M. M. Olmstead, D. J. Nurco, N. E. Schore, J. Zhang, J.-G. Ma, K. M. Smith, S. Gazeau, J. Pécaut, J.-C. Marchon, C. J. Medforth and J. A. Shelnett. 2005. Energetics and structural consequences of axial ligand coordination in nonplanar nickel porphyrins. J. Am. Chem. Soc., 127, 1179.
- Ockey, D.A., M.A. Lewis and N.E. Schore. 2003. A short synthesis of (±)-tecomanine via a Pauson-Khand-based route. Tetrahedron, 58, 5377.
- Price, M.D., J.K. Sui, M.J. Kurth and N.E. Schore. 2002. Oxazaborolidenes as functional monomers: ketone reduction using polymer-supported CBS catalysts. J. Org. Chem., 67, 8086.
- Price, M.D., M.J. Kurth and N.E. Schore. 2002. Comparison of solid phase and solution phase chiral auxiliaries in the alkylation/iodolactonization sequence to ?-butyrolactones. J. Org. Chem., 67, 7769.
- Hok, S., J. Vassilian and N.E. Schore. 2002. Catalytically active, recyclable zirconocene supported at crosslinks within porous polymer disks. Org. Lett., 4, 2365.
- Cutter, P.S., R.B. Miller and N.E. Schore. 2002. Synthesis of Protoberberines using a silyl-directed Pictet-Spengler cyclization. Tetrahedron, 58, 1471.