Graphical abstract summarizing antidepressant effects of DMT administration in rodents.

Hallucinogenic Compound in Ayahuasca Shows Therapeutic Promise

Ayahuasca, a traditional Amazonian tisane used in religious and healing ceremonies, contains a complex mixture of psychoactive natural products.  The Olson Lab has recently discovered that N,N-dimethyltryptamine (DMT), the principal hallucinogenic alkaloid in this concoction, produces antidepressant effects in rodents and reduces fear in an animal model of post-traumatic stress disorder (PTSD).  This work highlights the potential for using psychedelics and related compounds for treating neuropsychiatric disorders.

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