Crystal Structure of the [FeFe]-Hydrogenase Maturase HydE Bound to Complex-B

Crystal structure of HydE bound to Complex-B

The collaboration of the Britt and Rauchfuss (UIUC) labs with the Nicolet group at Grenoble has revealed the structure of the Fe(II)(CO)2(CN)cysteine organometallic product of the HydG Fe-Fe hydrogenase “maturase” enzyme as bound and activated towards dimerization by HydE, the second radical SAM maturase enzyme in the hydrogenase H-cluster biosynthetic pathway.

Further information available at: https://pubs.acs.org/doi/pdf/10.1021/jacs.1c03367