Professor Liu’s overall research objective focuses on the development of nanotechnology and potential applications to bioanalytical chemistry. One important aspect of the research is the design and engineering of nanostructures which position bioreceptors and chemical reaction sites on surfaces with high precision. The exquisite precision attainable by the nanolithographic methods developed allows complex multivalent interactions typical of biorecognition to be controlled, by varying the separation and local environment of the binding sites. Current projects include: (1) development of state-of-the-art imaging tools for high-resolution imaging of ligands, DNA, proteins and cells; (2) advanced methodologies for production of arrays of nanostructures; (3) single-cell imaging and mechanics; (4) using nanostructures of antibodies produced to investigate hypersensitivity reaction or allergy; (5) using nanostructures of ligands for study of the initial HIV infection of human T-cells; and (6) using nanostructures of ligands for the investigation of cancer cell signaling.
Education, Awards and Professional Highlights
- ACS Fellow (2010)
- AAAS Fellow (2007)
- Appointed to UC Davis faculty (2001)
- Career Development Chair Award, Wayne State University (2000-2001)
- Outstanding Scholarly Achievement Award, Wayne State University (2000)
- Associate Professor, Wayne State University (1999-2001)
- NSF CAREER Award (1997-2001)
- Arnold and Mabel Beckman Young Investigator Award (1996-1998)
- Camille and Henry Dreyfus New Faculty Award (1994-1999)
- Assistant Professor, Wayne State University (1994-1999)
- Miller Research Fellowship, University of California, Berkeley (1992-1994)
- Harold W. Dodds Honorific Fellowship, Princeton University (1990-1991)
- CGP (Chemistry Graduate Program) Fellowship, Princeton University (1986-1987)
- Ph.D. Princeton University (1992)
- M.A. Princeton University (1987)
- B.S. Peking (Beijing) University, P. R. China (1985)
- "Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukemia Cells." Li, J-R.; Ross, S. S.; Liu, Y.; Liu, Y. X.; Wang, K-h.; Chen, H-Y.; Liu, F-T.; Laurence, T. A.; Liu, G-y. ACS Nano, 2015, 9 (7), pp 6738–6746. (Cover image).
- “New Approach to Investigate the Cytotoxicity of Nanomaterials Using Single Cell Mechanics.” Zimmer, C. C.; Liu, Y. X.; Morgan, J. T.; Yang, G.; Wang, K. H.; Kennedy, I. M.; Barakat, A. I.; Liu, G. Y. J. Phys. Chem. B 2014, 118(5), 1246-1255.
- “Near-Field Scanning Optical Microscopy Enables Direct Observation of Moir Effects at the Nanometer Scale.” Lin, W. F.; Li, J-R.; Liu, G. Y. ACS Nano 2012, 6(10), 9141-9149.
- “Nanostructures of Deigned Geometry and Functionality Enable Regulation of Cellular Signaling Processes.” Li, J-R.; Shi, L.; Deng, Z.; Lo, S. H.; Liu, G. Y. Biochemistry 2012, 51(30), 5876-5893.
- “Engineered Nanostructures of Antigen Provide an Effective Means for Regulating Mast Cell Activation.” Deng, Z.; Weng, I-C.; Li, J-R.; Chen, H-Y.; Liu, F-T.; Liu, G. Y. ACS Nano 2011, 5(11), 8672-8683.
- “Single Cell Mechanics Provides a Sensitive and Quantitative Means for Probing Aβ Peptide - Neuronal Cell Interactions.” Lulevich, V.; Zimmer, C.; Hong, H. S.; Jin, L. W.; Liu, G. Y. PANS 2010, 107(31), 13872–13877.