Claude Meares

Claude Meares

Position Title
Professor Emeritus


Bioconjugate chemistry, molecular biology, application of chemical techniques to biological and biomedical problems, mapping protein-protein and protein-nucleic acid interactions, bifunctional chelating agents, engineered antibodies.

Education, Awards and Professional Highlights

  • Fellow, American Chemical Society (2010)
  • Immunomedics Science Award, 1998 Association for Laboratory Automation Achievement Award (2002)
  • Fellow, American Association for the Advancement of Science (1994)
  • Distinguished Scientist Award, Society of Nuclear Medicine, Western Region (1994)
  • Appointed to Faculty, UC Davis (1972)
    • Dept. Chair (1997-2000)
  • Ph. D., Stanford University (1972)
  • B. S., University of North Carolina, awarded with highest honors (1968)

Reperesentative Publications

  • Meares, Claude F.; Chmura, A. J.; Orton, Molly S.; Corneillie, Todd M.; Whetstone, Paul A. Molecular tools for targeted imaging and therapy of cancer. Journal of Molecular Recognition 16(5), 255-259 (2003).
  • Corneillie, Todd M.; Fisher, Andrew J.; Meares, Claude F. Crystal Structures of Two Complexes of the Rare-Earth-DOTA-Binding Antibody 2D12.5: Ligand Generality from a Chiral System. Journal of the American Chemical Society 125(49), 15039-15048 (2003).
  • Meares CF, Datwyler SA, Schmidt BD, Owens J, Ishihama A. Principles and methods of affinity cleavage in studying transcription. Methods Enzymol. 371:82-106 (2003).
  • Paul A. Whetstone, Nathaniel G. Butlin, Todd M. Corneillie, and Claude F. Meares. Element-Coded Affinity Tags for Peptides and Proteins. Bioconjugate Chemistry 15(1), 3-6 (2004).
  • Whetstone PA, Akizawa H, Meares CF. Evaluation of Cleavable (Tyr(3))-octreotate Derivatives for Longer Intracellular Probe Residence. Bioconjug Chem. 2004 May-Jun;15(3):647-57.
  • Corneillie TM, Whetstone PA, Lee KC, Wong JP, Meares CF. Converting weak binders into infinite binders. Bioconjugate Chem. 2004;15(6):1389-1391.
  • Corneillie TM, Lee KC, Whetstone PA, Wong JP, Meares CF. Irreversible Engineering of the Multielement-Binding Antibody 2D12.5 and Its Complementary Ligands. Bioconjugate Chem. 2004;15(6):1392-1402.
  • Richman CM, Denardo SJ, O'Donnell RT, Yuan A, Shen S, Goldstein DS, Tuscano JM, Wun T, Chew HK, Lara PN, Kukis DL, Natarajan A, Meares CF, Lamborn KR, DeNardo GL. High-dose radioimmunotherapy combined with fixed, low-dose paclitaxel in metastatic prostate and breast cancer by using a MUC-1 monoclonal antibody, m170, linked to indium-111/yttrium-90 via a cathepsin cleavable linker with cyclosporine to prevent human anti-mouse antibody. Clin Cancer Res. 2005 Aug 15;11(16):5920-7.
  • Lee S, Young NL, Whetstone PA, Cheal SM, Benner WH, Lebrilla CB, Meares CF. Method to site-specifically identify and quantitate carbonyl end products of protein oxidation using oxidation-dependent element coded affinity tags (O-ECAT) and nanoliquid chromatography Fourier transform mass spectrometry. Journal of Proteome Research 2006; 5 (3): 539-547.
  • Corneillie TM, Whetstone PA, Meares CF. Irreversibly binding anti-metal chelate antibodies: Artificial receptors for pretargeting. J Inorg Biochem. 2006 May;100(5-6):882-90.
  • Butlin NG, Meares CF. Antibodies with infinite affinity: origins and applications. Acc Chem Res. 2006 Oct;39(10):780-7. (Cover Article)