Andrew Fisher

Andy Fisher

Position Title

4A Briggs

X-ray crystallography is one of the most powerful tools to examine protein structure at atomic detail. My laboratory uses single crystal x-ray diffraction techniques to determine the three-dimensional structure of biologically important proteins. Knowledge of the atomic resolution structure provides tremendous insight into understanding how the protein functions. Hypotheses on structure - function relationships can be drawn from the crystal structure, which can be tested using crystallography and other biophysical and biochemical techniques. Currently, the laboratory is focusing on enzymes in the biologically important pathways of RNA editing, sulfate activation, and glycobiology.

Education, Research and Professional Highlights

  • Appointed to UC Davis Molecular and Cellular Biology faculty (1996)
  • Appointed to UC Davis Department of Chemistry faculty (1996)
  • NIH Postdoctoral fellow, University of Wisconsin-Madison (1992-1996)
  • Linus Pauling Prize, American Crystallographic Association (1991)
  • Ph.D. Biophysics, Purdue University (1992)
  • B.S. Biochemistry, Purdue University (1987)

Representative Publications

  • Fisher, A. J., and Beal, P. A. (2017). Effects of Aicardi-Goutières Syndrome Mutations Predicted from ADAR-RNA Structures. RNA Biology14:164-170. [PDF Reprint]
  • Lal, N. K., Fisher, A. J. and Dinesh-Kumar, S. P. (2016) Arabidopsis receptor-like cytoplasmic kinase BIK1: purification, crystallization, and X-ray diffraction analysis. Acta Cryst. F72:738-742. [PDF Reprint]
  • Kohler, A. C., Chen, L.-H., Hurlburt, N., Salvucci, A., Schwessinger, B., Fisher, A. J. and Stergiopoulos, I. (2016) Structural analysis of an Avr4 effector ortholog offers insight into chitin-binding and recognition by the Cf-4 receptor. Plant Cell. 28:1945-1965. [PDF Reprint]
  • *Matthews, M. M., *Thomas, J. M., Zheng, Y., Tran, K., Phelps, K. J., Scott, A. I., Havel, J., Fisher, A. J., and Beal, P. A. (2016). Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat. Struct. Mol. Biol23:426-433. [PDF Reprint] 
  • Erickson, A. I., Sarsam, R. D., and Fisher, A. J. (2015) Structures of Mycobacterium tuberculosis CysQ, with substrate and products bound. Biochemistry 54:6830-6841. [PDF Reprint]
  • Ngo, A., Fong, K. T., Cox, D. L., Chen, X., and Fisher, A. J. (2015) Structure of Bacteroides fragilis uridine 5’-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA). Acta CrystD71:1068-1076. [PDF Reprint]
  • Phelps, K., Tran, K., Eifler, T., Erickson, A. I., Fisher, A. J., and Beal, P. A. (2015) Recognition of Duplex RNA by the Deaminase Domain of the RNA Editing Enzyme ADAR2. Nucleic Acids Res43:1123-1132. [PDF Reprint]
  • Huynh, N., Li, Y., Hai Y., Huang, S., Lau, K., Chen, X., and Fisher, A. J. (2014) Crystal Structures of Sialyltransferase from Photobacterium damselaeFEBS Lett588:4720-4729. [PDF Reprint]