Stephen P. Cramer

Professor Stephen Cramer

Professor Stephen Cramer

Ph.D. Stanford University

Stephen P. Cramer, whose research straddles the fields of synchrotron x-ray spectroscopy and bio-inorganic chemistry, is an Advanced Light Source Professor at UC Davis and Lawrence Berkeley National Laboratory. He became involved with synchrotron radiation in 1974, during thesis work on the EXAFS of nitrogenase at Stanford's SSRP. Following an NIH post-doc with Harry Gray, he joined Exxon Research, where he used EXAFS and other methods to characterize man-made and biological catalysts. Since then, he has worked on developing new synchrotron methods for characterizing metals in biology. These include the first bioinorganic applications of soft x-ray magnetic circular dichroism (XMCD) and resonant inelastic x-ray scattering (RIXS). More recently, his group has employed nuclear resonance vibrational spectroscopy (NRVS) and femtosecond pump probe spectroscopy (FPPS), as well conventional methods such as FT-IR, resonance Raman, and Mössbauer spectroscopy.
(530) 752-0360

Education, Awards and Professional Highlights

  • Senior Faculty Scientist Physical Biosciences Division, Lawrence Berkeley Lab (1991-Present)
  • Advanced Light Source Professor Department of Applied Science, UC Davis (1991-Present)
  • Physicist, National Synchrotron Light Source, Brookhaven National Lab (1988-1990)
  • Member of Professional Staff Schlumberger-Doll Research (1986-1988)
  • Senior Staff Chemist and Group Head, Exxon Research (1978-1986)
  • California Institute of Technology - NIH post-doc with Prof. Harry Grayi (1978)
  • Ph.D. Stanford University (1978)
  • B.A. Williams College (1973)

Representative Publications

  • "Steric Control of the of Hi-CO MoFe Nitrogenase Complex Revealed by Stopped-Flow Infra-red Spectroscopy", Yang, Z.-Y.; Seefeldt, L. C.; Dean, D. R.; Cramer, S. P.; George, S. J. Angew. Chem., 2011, 123, 286-289.
  • "Photolysis of 'Hi-CO' Nitrogenase - Observation of a Plethora of Distinct CO Species via Infrared Spectroscopy", Yan, L.; Dapper, C. H.; George, S. J.; Wang, H.-X.; Mitra, D.; Dong, W.-B.; Newton, W. E.; Cramer, S. P. Eur. J. Inorg. Chem., 2011, 2011, 2064-2074.
  • "Cell-free H-cluster Synthesis and [FeFe] Hydrogenase Activation: All Five CO and CN- Ligands Derive from Tyrosine", Kuchenreuther, J. M.; George, S. J.; Grady-Smith, C. S.; Cramer, S. P.; Swartz, J. R. PLoS ONE, 2011, 6, e20346.
  • "Dynamics of the [4Fe-4S] Cluster in Pyrococcus furiosus D14C Ferredoxin via Nuclear Resonance Vibrational and Resonance Raman Spectroscopies, Force Field Simulations, and Density Functional Theory Calculations", Mitra, D.; Pelmenschikov, V.; Guo, Y.; Case, D. A.; Wang, H.; Dong, W.; Tan, M.-L.; Ichiye, T.; Francis E. Jenney, J.; Adams, M. W. W.; Yoda, Y.; Zhao, J.; Cramer, S. P. Biochemistry, 2011, 50, 5220-5235.
  • "Observation of dd excitations in NiO and NiCl2 using K-edge resonant inelastic x-ray scattering", van Veenendaal, M.; Liu, X.; Carpenter, M. H.; Cramer, S. P. Phys. Rev. B, 2011, 83, 045101.
  • "Characterization of a Synthetic Peroxodiiron(III) Protein Model Complex by Nuclear Resonance Vibrational Spectroscopy", Do, L. H.; Wang, H.; Tinberg, C. E.; Dowty, E.; Yoda, Y.; Cramer, S. P.; Lippard, S. J. Chem. Commun., 2011, 47, 10945-10947.
  • "EXAFS and NRVS Reveal a Conformational Distortion of the FeMo-cofactor in the MoFe Nitrogenase Propargyl Alcohol Complex", George, S. J.; Barney, B. M.; Mitra, D.; Igarashi, R. Y.; Guo, Y.; Dean, D. R.; Cramer, S. P.; Seefeldt, L. C. J. Inorg. Biochem., 2012, 112, 85-92.
  • "Exploration of Synchrotron Massbauer Microscopy with Micron Resolution: Forward and a New Backscattering Modality on Natural Samples", Yan, L.; Zhao, J.; Toellner, T. S.; Divan, R.; Xu, S.; Cai, Z.; Boesenberg, J. S.; Friedrich, J. M.; Cramer, S. P.; Alp, E. E. J. Syn. Rad., 2012, 19, 814-820.
  • "Nuclear Resonance Vibrational Spectroscopy (NRVS) of Rubredoxin and MoFe Protein Crystals", Guo, Y.; Brecht, E.; Aznavour, K.; Nix, J. C.; Xiao, Y.; Wang, H.; George, S. J.; Bau, R.; Stephen Keable; Peters, J. W.; Adams, M. W. W.; Jenney Jr., F. E.; Sturhahn, W.; Alp, E. E.; Zhao, J.; Yoda, Y.; Cramer, S. P. Hyperfine Interact., 2012, in press.
  • "Nuclear Resonance Vibrational Spectroscopy (NRVS) Studies of NiFe Hydrogenase - Observation of Active Site Fe-CN and Fe-CO Normal Modes", Kamali, S.; Ogata, H.; Lubitz, W.; Rauchfuss, T.; Wang, H.; Yoda, Y.; Zhao, J.; Cramer, S. P. Angew. Chem. Int. Ed., 2012, in press.