Andrew J. Fisher

Professor Andy Fisher

Professor Andy Fisher

Professor
Ph.D. Purdue University

X-ray crystallography is one of the most powerful tools to examine protein structure at atomic detail. My laboratory uses single crystal x-ray diffraction techniques to determine the three-dimensional structure of biologically important proteins. Knowledge of the atomic resolution structure provides tremendous insight into understanding how the protein functions. Hypotheses on structure - function relationships can be drawn from the crystal structure, which can be tested using crystallography and other biophysical and biochemical techniques. Currently, the laboratory is focusing on enzymes in the biologically important pathways of; sulfate activation, sialic acid transfer, and chromophore biosynthesis.

ajfisher@ucdavis.edu
4462 Chemistry Annex, 4A Briggs
(530) 754-6180
http://chemgroups.ucdavis.edu/~fisher

Protein Folding animated Gif

Education, Research and Professional Highlights

  • Appointed to UC Davis Molecular and Cellular Biology faculty (1996)
  • Appointed to UC Davis Department of Chemistry faculty (1996)
  • NIH Postdoctoral fellow, University of Wisconsin-Madison (1992-1996)
  • Linus Pauling Prize, American Crystallographic Association (1991)
  • Ph.D. Biophysics, Purdue University (1992)
  • B.S. Biochemistry, Purdue University (1987)

Representative Publications

  • Erickson, A. I., Sarsam, R. D., and Fisher, A. J. (2015) Structures of Mycobacterium tuberculosis CysQ, with substrate and products bound. Biochemistry 54:6830-6841. [PDF Reprint]
  • Ngo, A., Fong, K. T., Cox, D. L., Chen, X., and Fisher, A. J. (2015) Structure of Bacteroides fragilis uridine 5’-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA). Acta Cryst. D71:1068-1076. [PDF Reprint]
  • Phelps, K., Tran, K., Eifler, T., Erickson, A. I., Fisher, A. J., and Beal, P. A. (2015) Recognition of Duplex RNA by the Deaminase Domain of the RNA Editing Enzyme ADAR2. Nucleic Acids Res. 43:1123-1132. [PDF Reprint]
  • Huynh, N., Li, Y., Hai Y., Huang, S., Lau, K., Chen, X., and Fisher, A. J. (2014) Crystal Structures of Sialyltransferase from Photobacterium damselae. FEBS Lett. 588:4720-4729. [PDF Reprint]
  • Phelps, K., Ibarra-Soza, J. M., Tran, K., Fisher, A. J., and Beal, P. A. (2014). Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA. ACS Chem. Bio. 9:1780-1787. [PDF Reprint]
  • Huynh, N., Aye, A., Li, Y., Yu, H., Cao, H., Tiwari, V. K., Shin, D.-W., Chen, X., and Fisher, A. J. (2013) Structural basis for substrate specificity and mechanism of N-acetyl-D-neuraminic acid lyase from Pasteurella multocida. Biochemistry. 52:8570-8579. [PDF Reprint]